This analysis is defined as a method for problem solving in the preparation of untreated synthesis in
synthetic organic chemistry. The process is attained by transformation of a target particle to simpler
forerunner elements without starting materials assumptions.
The same method is used to examine each precursor material. The procedure is then repeated until
commercially available simple structures are gotten. The concept was formalized b E.J Corey in 1990
and he received a Nobel Prize in chemistry for this reason
Structural simplification is the main goal of retrosynthesis in synthetic organic chemistry. A process
will often have multiple synthetic routes to complete the process. In case of identifying multiple
methods, then this process is well suited and it compares them in a straightforward and logical
fashion. In order to decide if a module exists already in the process at each stage, then a database may
be consulted. No further compound exploration will be required in case.
Below are terms in retrosynthetic analysis in synthetic organic chemistry you should know;
Retron- it is a molecular substructure that makes certain transformation possible
Retrosynthetic tree- this is a directed acyclic graph of several possible retrosyntheses of a
Disconnection- it is a step in retrosynthetic that involves the breaking of a bond to form more
Target- this is the desired final compound
Synthon- it is an idealized molecular fragment that corresponds commercially available
Transform- this is the synthetic reaction in the reverse. It is the formation of starting materials
from a single product.
Below are different strategies involved in retrosynthetic analysis in synthetic organic chemistry
Functional group strategies
Stereoc hemical strategies
Structure goal strategies
Transform based strategies